Cardiovascular: Platelets - Thrombosis Adhesion Assay
Novel microflow system | Low flow rates (5 pL min-1 to 10 μL min-1) and shear stress levels
top of page
Cellix Technical Team
- Jan 9
- 3 min
Cellix's VenaFlux Solutions mimic human blood vessels
Quantify cell adhesion, rolling, migration, cell-cell adhesion, platelet aggregation, thrombi ormation - all under shear flow.
450
Cellix Technical Team
- Nov 22, 2022
- 3 min
A role for SHARPIN in platelet linear protein ubiquitination and function – By Moore et al. (2021).
Role of SHARPIN in regulating platelet function | Perfusing whole blood | Accumulation on collagen | Reduced linear ubiquitination
1850
Cellix Technical Team
- Nov 14, 2022
- 8 min
Cardiovascular: Atherosclerosis Monocyte Adhesion - chemokines -oxidised LDL
Role of different stimuli recognised to play an important part in atherosclerosis development | Leukocyte adhesion to endothelial cells |
1310
Cellix Technical Team
- Oct 10, 2022
- 3 min
P-selectin targeting polysaccharide-based nano-gels for miRNA delivery
Targeting assays | fluorescence microscopy | miRNA-based therapeutics in atherothrombotic diseases
1650
Cellix Technical Team
- Jul 4, 2022
- 3 min
People are talking about our food
Thrombus formation under flow in vitro | Treatment with cucurbitacin | Pre-incubation of platelets with cucurbitacins
1621
Cellix Technical Team
- May 31, 2022
- 4 min
Selective Adenosine Receptor (AR) ligands modulate AR activity showing promise as clinical candidate
Inhibition of human blood platelets aggregation | Inhibition of human blood platelets aggregation | Formation of thrombus in flow conditions
2560
Cellix Technical Team
- May 6, 2022
- 3 min
Bleeding diathesis in mice lacking JAK2 in platelets
The tyrosine kinase JAK2 protein is critical for the JAK/STAT cytokine signaling of hematopoietic cells. The somatic JAK2 V617F mutation...
1780
Cellix Technical Team
- Apr 8, 2022
- 4 min
Inhibition of NADPH oxidase blocks NETosis & reduces thrombosis in heparin-induced thrombocytopenia
Microfluidic studies | Neutrophil-targeted ROS-inhibition assays | Thrombus formation in HIT requires neutrophil-derived ROS
2770
Cellix Technical Team
- Mar 21, 2022
- 4 min
NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia
NETosis markers | Thrombosis induction | VITT antibodies induce thrombosis and thrombocytopenia in vitro
3150
Cellix Technical Team
- Feb 25, 2022
- 4 min
Eucalyptol Inhibits Agonist-induced Platelet Function and Thrombus Formation in Mice
Thrombus Formation | Integrin αIIbβ3 Signaling | Granule Secretion in Platelets | Hemostasis
1030
Cellix Technical Team
- Jan 24, 2022
- 4 min
Nanovesicles dissolve blood clots reducing side-effects
How does the nanovesicle work | Thrombus selectivity under physiological flow conditions | Targeted thrombolysis under flow conditions |
2750
Cellix Technical Team
- Oct 11, 2021
- 4 min
Harnessing seaweed extract to treat ischemic stroke
On this World Thrombosis Day and in advance of World Stroke Day, taking place on 29th October, we’d like to shine a light on a paper recentl
1900
Cellix Technical Team
- Aug 23, 2021
- 4 min
Blood clots in severely ill COVID-19 patients caused by abnormal antibody response
New study reveals blood clotting in critically ill COVID-19 may be caused by an excessive immune response rather than the virus itself.
333
Cellix Technical Team
- May 18, 2021
- 5 min
Assessing Plasma Infusion in cTTP patients with the VenaFlux platform
Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare blood clotting disorder. Currently, there is no method to assess the...
4280
Cellix Technical Team
- Apr 20, 2021
- 4 min
Shear Rate - what's it got to do with platelet adhesion?
As a thrombus (blood clot) grows in size, the blood has to be diverted over and around it. In order for blood flow to be maintained, the blo
1,2270
Cellix Technical Team
- Mar 15, 2021
- 4 min
Standardised modelling of microclots in COVID-19 patients
Researchers set out to investigate if the spike protein interfered with blood flow, comparing naïve healthy PPP samples, with and without ad
8530
Cellix Technical Team
- Oct 13, 2020
- 3 min
Trapped! Flow studies reveal Thrombosis target
The researchers of this study focused on how recruited platelets interact with neutrophils and whether this promotes the onset of Deep Vein
2401
Dmitry Kashanin, CTO, Cellix
- Aug 18, 2020
- 3 min
Cellix Solutions model inflammation to accelerate your COVID-19 research
In this newsletter, we continue to explore how Cellix’s VenaFlux Solutions can help researchers to study mechanisms involved in the...
2570
Vivienne Williams
- Jul 30, 2020
- 3 min
Cellix Solutions model endothelial dysfunction for COVID-19 research
In the current phase of Coronavirus SARS-Cov-2 pandemic, there is mounting research evidence that COVID-19 disease has a significant...
3810
bottom of page