Intravenous abciximab as a rescue therapy in stroke patients

By Delvoye et al., 2021

Background

Recanalization involves the adhesion of the thrombus to the vein wall. An inflammatory response leads to thrombus contraction and spontaneous lysis of the thrombus. Durable recanalization is typically linked to a good clinical outcome after mechanical thrombectomy (MT) in acute ischemic stroke patients (AIS).

Lack of recanalization occurs due to an impossibility of retrieving the occlusive clot or an immediate reocclusion after the initial recanalization, which happens in 19% of the cases.

Evidence shows that patients with an elevated platelet count at admission were more likely to have early reocclusion after successful MT. So, platelets may play an essential role in immediate reocclusion in AIS patients.