Microenvironmental Chamber

Temperature controlled microscope frame for microfluidic chips

 
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TEMPERATURE CONTROLLED: Room temperature to 50 degC. For convenience, there is one presetting of 37degC.

SET DESIRED TEMPERATURE EASILY WITH +/- BUTTONS

CHIP DIMENSIONS:  The frame will hold microfluidic chips of size 50mm (L) x 40mm (W) x 3mm (D).  Compatible with Cellix's Vena biochip range.

COMPATIBLE WITH WIDE RANGE OF MICROSCOPES: including Zeiss, Nikon etc.

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HOW DOES IT WORK?

The frame contains 2 heater blocks on each side of the section where the microfluidic chip is placed and a sensor which measures the temperature of the microfluidic chip. The temperature of the microfluidic chip is shown in red on the temperature controller.  The top of the frame contains an ITO glass slide (Indium Tin Oxide, a transparent conductor).  The ITO glass slide heats the surface of the microfluidic chip to the desired temperature setting, shown in green on the temperature controller.

Microenvironmental chamber - how does it work?
Microenvironmental chamber - how does it work?

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Micro-environmental Chamber with controller
Micro-environmental Chamber with controller

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Micro-environmental Chamber with controller
Micro-environmental Chamber with controller

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Microenvironmental chamber - how does it work?
Microenvironmental chamber - how does it work?

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Experimental Set-ups

Micro-environmental Chamber with controller and ExiGo
Micro-environmental Chamber with controller and ExiGo

ExiGo pump connected to microfluidic chip placed in microenvironmental chamber.

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Micro-environmental Chamber with controller and UniGo
Micro-environmental Chamber with controller and UniGo

UniGo pump connected to microfluidic chip via 8-way splitter.

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Micro-environmental Chamber with controller and ExiGo
Micro-environmental Chamber with controller and ExiGo

ExiGo pump connected to microfluidic chip placed in microenvironmental chamber.

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APPLICATIONS

  • Organ-on-chip studies

  • Thrombosis / Platelet Adhesion and Aggregation shear flow experiments.

  • Shear based cell rolling, adhesion and transmigration assays on ligand-coated surface or on endothelial cells for studies in:

    • Inflammation​:  leukocyte and T-cell adhesion studies for sepsis, statins, immunological disorders.

    • Asthma & Allergies: eosinophil adhesion studies for anti-inflammatories, antihistamines (e.g. cetirizine/levocetirizine - montelukast).

    • Oncology:  melanoma cell adhesion and metastasis

    • Bacteria:  E. coli adhesion and biofilm formation

 

RELATED PRODUCTS

Cellix biochips

Microfluidic Chips

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Microfluidic Pumps

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Tubing & Connectors

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Sample Reservoirs