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VenaFlux for thrombosis: Installation and training guide

Quantify cell adhesion, rolling, migration, cell-cell adhesion, platelet aggregation, thrombi formation - all under shear flow

Introduction

The circulatory system contains many different types of blood vessels which delivers blood cells, nutrients, oxygen, carbon dioxide and hormones to all parts of the body. Blood vessels play a huge role in many medical conditions such as:

  • Thrombosis

  • Inflammation

  • Atherosclerosis

​VenaFlux Solutions comprise packages to suit all budgets, with our Starter kit including a precision microfluidic pump, a microenvironmental chamber to hold the biochips which contain engineered microcapillaries and cell analysis software; to Pro and Elite versions including high-end fluorescent microscopes with a digital camera. The VenaFluxAssay software integrates the microfluidic pump, microscope and camera resulting in a complete automated high-throughput flow assay system for shear stress experiments.

  • COST EFFECTIVE SOLUTION - integrate with your own inverted microscope.

  • THROMBOSIS, PLATELET ADHESION & AGGREGATION ASSAYS: 2.25 - 450 dyne/cm with Vena8 Fluoro+ Biochips.

  • CELL-LIGAND & CELL-CELL ROLLING, ADHESION & MIGRATION SHEAR FLOW ASSAYS: 0.05 - 10 dyne/cm with Vena8 Fluoro+ and Vena8 Endothelial+ Biochips.

  • MULTIPLEXED ASSAYS with Mirus Evo Pump and MultiFlow8 providing equal flow rates in 8 channels of Cellix's biochips. This enables multiple cell types or adhesion molecules to be tested simultaneously comparing different therapeutic treatments.

  • TEMPERATURE CONTROLLED CONDITIONS mimicking physiological conditions with microenvironmental chamber.

  • CELL ANALYSIS of % thrombus coverage and number of thrombi; number of cells adhered to protein-coated channels and analysis of rolling velocities of cells.

  • PROGRAMMABLE with PC-controlled VenaFluxAssay software enabling execution of customised protocols.

VenaFlux Solutions

VenaFlux Solutions comprise packages to suit all budgets. The four packages are as follows:

Does Cellix provide product installation and training? 

Product Installation:

  • VenaFlux Basic:  Conducted online and it usually takes minutes to set-up the ExiGo pump but the customer should allow ~1hr so that we can explain everything to them, including the SmartFlo software.

  • VenaFlux Starter:  Conducted online and it usually takes ~1hr to set-up the Mirus pump with the MultiFlow8 including priming/washout in preparation to begin the assay.  The customer should allow ~2hrs so that we can explain everything to them, including the VenaFluxAssay software.

  • VenaFlux Pro:  Conducted on-site by Cellix's trained personnel.  It usually takes ~1 day to install the VenaFlux Pro.

  • VenaFlux Elite: Conducted on-site by Cellix's trained personnel.  It usually takes ~1 day to install the VenaFlux Elite.

Product Training: 

  • VenaFlux Basic:  Conducted online and it usually takes ~1-2 hours so that we can explain everything to them, including the SmartFlo software.  Before product training, our applications specialist Toby Paul, will contact the customer to ensure they have the reagents required to do the experiments.  

  • VenaFlux Starter:  Conducted online and it usually takes ~1-2 hours so that we can explain everything to them, including the SmartFlo software.  Before product training, our applications specialist Toby Paul, will contact the customer to ensure they have the reagents required to do the experiments.  

  • VenaFlux Pro:  Conducted on-site by Cellix's trained personnel.  It usually takes ~3 days to train users on the VenaFlux Pro.  Before product training, our applications specialist Toby Paul, will contact the customer to ensure they have the reagents required to do the experiments.

  • VenaFlux Elite: Conducted on-site by Cellix's trained personnel.  It usually takes ~3 days to train users on the VenaFlux Elite.  Before product training, our applications specialist Toby Paul, will contact the customer to ensure they have the reagents required to do the experiments.

Training Charges: 

  • VenaFlux Basic:  Training is recommended but optional.  It is conducted online and costs €395.  This includes assistance with installation.

  • VenaFlux Starter:  Training is recommended but optional.  It is conducted online and costs €395.  This includes assistance with installation.

  • VenaFlux Pro:  Training is compulsory and included with the purchase of the VenaFlux Pro.  It is conducted on-site by Cellix's trained personnel and usually takes ~3 days.

  • VenaFlux Elite: Training is compulsory and included with the purchase of the VenaFlux Elite.  It is conducted on-site by Cellix's trained personnel and usually takes ~3 days.

If the customer has not already viewed the following videos, we recommend that they do so before training. These videos will help the customer understand how to use the ExiGo pump for thrombosis experiments:​


How to pre-coat a Vena8 Fluoro+ Biochip

Demo of Thrombosis Assay using Cellix's VenaFlux Basic setup with ExiGo pump

Demo of Thrombosis Assay using Cellix's VenaFlux Starter setup with Mirus pump

The products mentioned above are available on our eShop. If you have any questions just drop us a mail at info@wearecellix.com. All our products are customisable to the needs of our customers. Talk to us about solutions that serve your goals best.

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