VenaFlux Starter

Mirus Evo Pump, Microenvironmental Chamber &

Image Pro Cell Analysis Software

COST EFFECTIVE SOLUTION - integrate with your own inverted microscope.

THROMBOSIS, PLATELET ADHESION & AGGREGATION ASSAYS: 2.25 - 450 dyne/cm with Vena8 Fluoro+ Biochips.

CELL-LIGAND & CELL-CELL ROLLING, ADHESION & MIGRATION SHEAR FLOW ASSAYS: 0.05 - 10 dyne/cm with Vena8 Fluoro+ and Vena8 Endothelial+ Biochips.

MULTIPLEXED ASSAYS with Mirus Evo Pump and MultiFlow8 providing equal flow rates in 8 channels of Cellix's biochips. This enables multiple cell types or adhesion molecules to be tested simultaneously comparing different therapeutic treatments.

TEMPERATURE CONTROLLED CONDITIONS mimicking physiological conditions with microenvironmental chamber.

CELL ANALYSIS of % thrombus coverage and number of thrombi; number of cells adhered to protein-coated channels and analysis of rolling velocities of cells.

PROGRAMMABLE with PC-controlled VenaFluxAssay software enabling execution of customised protocols.

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HOW DOES IT WORK?

VenaFlux Starter contains the following products:

Mirus Evo Pump with MultiFlow8 controlled by VenaFluxAssay (desktop version), with tubing kits and cables.
Microenvironmental chamber
Cell Analysis Software: Image Pro Premier

As seen in the image below, the PC with VenaFluxAssay software is connected to the Mirus Evo Pump via USB connection. The Mirus Evo Pump tubing kit connects the Mirus Evo Pump to the MultiFlow8 and the MultiFlow8 Connect cable connects the MultiFlow8 to the biochip. The biochip is placed in the microenvironmental chamber which sits on the microscope stage*.

* Microscope not included with VenaFlux Starter.

Thrombosis

Analysis of Thrombus formation on Fibrillar collagen-coated microcapillaries of Vena8 Fluoro+ biochips using Image Pro Premier

Inflammation

Analysis of THP-1 cells adhesion on VCAM-coated microcapillaries of Vena8 Fluoro+ biochips using Image Pro Premier

Inflammation

Rolling velocity analysis of THP-1 cells on E-selectin-coated microcapillaries of Vena8 Fluoro+ biochips using Image Pro Premier

Thrombosis

Analysis of Thrombus formation on Fibrillar collagen-coated microcapillaries of Vena8 Fluoro+ biochips using Image Pro Premier

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How does it work?

APPLICATIONS

Thrombosis / Platelet Adhesion and Aggregation shear flow experiments.

Shear based cell rolling, adhesion and transmigration assays on ligand-coated surface or on endothelial cells for studies in:
- Inflammation: leukocyte and T-cell adhesion studies for sepsis, statins, immunological disorders.
- Asthma & Allergies: eosinophil adhesion studies for anti-inflammatories, antihistamines (e.g. cetirizine/levocetirizine - montelukast).
- Oncology: melanoma cell adhesion and metastasis
- Bacteria: E. coli adhesion and biofilm formation

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Thrombosis: Platelet adhesion to vWF coated biochip at 60 dyne/cm²

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Thrombosis: Platelet-leukocyte interaction at 2.25 dyne/cm² on collagen coated biochip

APPLICATION VIDEOS

Thrombosis

Platelet Aggregation

Blockage or closing of a blood vessel from a thrombus (blood clot) can lead to ischaemia (insufficient blood supply).

Inflammation

Cell adhesion & migration

Inflammation of the vessel wall is called vasculitis and is usually caused by leukocyte migration and resultant damage. This is often due to autoimmune disorders or infection.

Atherosclerosis

Plaque restricts blood flow

The narrowing of an artery due to the build-up of plaque (fatty deposits) - is one of the most common cardiovasular diseases, which can lead to one of many conditions including stroke or coronary artery disease.

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Applications