Interference of C604 on platelet aggregation pathways

Background

Perfluoroalkyl substances (PFAS) are synthetic compounds with surfactant properties, which you can find in many products like fire-extinguisher foams, soil-extraction additives, household detergents, and films, waterproof clothing, and coatings for cookware.

These compounds accumulate in the environment and humans, causing potential health issues. People living in nearby production plants of long-chain legacy PFAS such as perfluoro-octane sulfonic acid (PFOS) and perfluoro-octanoic acid (PFOA) are more likely to develop reproductive, metabolic, and cardiovascular diseases. The risks of exposure to short-chain PFAS are unknown.

Due to these concerns, the manufacturers discontinued PFOS and PFOA production. The fluorinated compound acetic acid, 2,2-difluoro-2-((2,2,4,5-tetrafluoro 5(trifluoromethoxy)-1,3-dioxolan-4-yl)oxy)-, ammonium salt (1:1), C6O4, could be a suitable substitute since it has lower environmental and tissue persistence due to its novel cycle di-ether structure.

However, reports have detected C604 in water and workers’ blood samples. So, researchers at the University of Padova, Italy,