Selective Adenosine Receptor (AR) ligands modulate AR activity showing promise as clinical candidate

Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B, and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists

Bednarska-Szczepaniak et al., 2021

Adenosine is an organic compound that is naturally present in the human body. It helps build RNA and many small molecules and supplies chemical energy for cells in the form of ATP. Adenosine interacts with the extracellular domain of G-protein coupled receptors (A1AR, A2AAR, A2BAR, and A3AR) and regulates nervous, circulatory, endocrine, and immunological functions.

The levels of adenosine increase in certain conditions like hypoxia, inflammation, or ischemia. This molecule acts as a protectant under these conditions and could be explored for therapeutic purposes. Already the A2A AR agonist regadenoson is being evaluated as an agent that reduces COVID-19-induced lung injury through inh