How do organs-on-a-chip allow more predictive drug discovery?
Drug discovery and development mostly rely on animal and cellular models. However, these models often fail to predict new drugs´ safety and efficacy in clinical trials.
Organ-on-a-chip platforms could provide a more accurate model for predicting drug response and potentially reduce the costs and time associated with pre-clinical drug development.
This article will discuss how this technology is changing drug screening and evaluation. We´ll also show you the minimum experimental setup to start working with organs-on-a-chip.
Current Challenges in Drug Discovery
Most preclinical studies use in vitro and animal models to assess the compound´s pharmacodynamics and pharmacokinetics. Cell cultures are widely used as in vitro models to study human disease and therapy. While 2D cell culture methods have evolved with time, they don´t represent the complex microenvironment of living tissues effectively,