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5 Fantastic Findings On Thrombosis Using Cellix Tech In 2019

Updated: Aug 28, 2020


With World Thrombosis Day just passed, we would like to look back over five publications, using #CellixTech, that have forwarded the world's knowledge of thrombosis. Thrombosis is often an integral part of the pathology of the world's most deadly cardiovascular diseases. This makes it currently responsible for one in four deaths around the world.

Cellix has had a close relationship with thrombosis research for a long time now as our microfluidic pumps and biochips have proven to be exceptionally useful in modelling blood flow in the body. The Vena8 Fluoro+, in particular, has allowed the scientific community to take great strides towards understanding the cardiovascular system in health and disease.

Although thrombosis is still a significant burden on the world, research in the field has changed our perspective on the conditions it causes. We now see the formation of thrombosis (and the diseases it causes) as largely preventable. To raise awareness of the brilliant work being done on thrombosis research we are going to take a look at some of the best publications using Cellix technology to come out within the last year.

 

Thrombosis formation.

 

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Researchers believe it may be possible to look at a person's individual ability to break down clots as a factor in predicting their risk of cardiovascular disease.

Impaired Spontaneous/Endogenous Fibrinolytic Status as New Cardiovascular Risk Factor?

One of our favorite publications to ever come out using Cellix tech was “Microfluidic Modeling of Thrombolysis” by Stéphane Loyau et. al in 2018. Here they used the Vena8 Fluoro+ chip to grow a platelet/fibrin-rich thrombus — also known as a blood clot — before passing specific drugs down the microfluidic channel to see how they affected the clot. The main aim was to look at the effects of drugs that broke apart the fibrin part of the clot. Hoping to see if the breakdown affected the platelet parts as well. Surprisingly, it turned out that the platelet parts continued to grow even when the fibrin parts were broken down.

More recently though, this research was then incorporated into a review of the body’s own ability to break down the fibrin part of blood clots — endogenous fibrinolysis. By using Cellix tech to understand the mechanisms involved in breaking down clots, it is now possible to assess whether these mechanisms are working correctly in patients dealing with thrombosis. The review found that impairments in a person's endogenous fibrinolysis system could be a prevalent risk factor in acute coronary syndrome. It’s exciting research as it can inform people of possible risks of cardiovascular problems in their future. With this information, proactive steps can be taken and lives will be saved.

Graphic from the review above - Gorog DA, Lip GYH.

 

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Scientists have discovered a novel coating that can lower the chances of infection from medical devices.

A Novel Medical Device Coating Prevents Staphylococcus aureus Biofilm Formation on Medical Device Surfaces