Vena8 Endothelial+

8-channel Microfluidic Cell Culture & Flow Chamber

PLUG & PLAY = LOW DEAD VOLUME with easy-to-connect tubing cables, no bulky luer connectors.

CELL CULTURE OF ENDOTHELIAL CELL MONOLAYERS IN MICROCHANNEL FLOW CHAMBERS with recirculating culture media via Kima pump.

CELL-CELL ADHESION SHEAR FLOW ASSAYS ON ENDOTHELIAL MONOLAYERS: 5 - 1,000 s with 100µL syringe; steps of 5 s with Exigo or Mirus Evo pumps.

COMPATIBLE WITH WIDE VARIETY OF CELL SAMPLES: whole blood, platelets, primary cells (T-cells, neutrophils, eosinophils etc.) and rare cells.

LOW SAMPLE VOLUME - even at high flow / shear rates with whole blood or cell suspensions.

REAGENT & CELL SAVINGS with only 10µL ligand/protein coating per channel (e.g. fibronectin to promote endothelial cell seeding) and only 5µL endothelial cell seeding per channel with standard pipette.

COMPATIBLE WITH STANDARD PIPETTES FOR EASY CELL SEEDING

COMPATIBLE WITH BRIGHTFIELD, PHASE CONTRAST IMAGING & FLUORESCENCE MICROSCOPY

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HOW DOES IT WORK?

Vena8 Endothelial+ Biochip detail

Cell-cell adhesion to endothelial cell monolayer under shear flow

Coating biochip with pipette

Easy to coat with protein or seed cells using standard pipette

Plug and Play tubing into Vena8 Biochip

Easy-to-connect tubing plugs directly into inlet of biochip; no dead volume

Vena8 Endothelial+ Biochip detail

Cell-cell adhesion to endothelial cell monolayer under shear flow

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DOWNLOADS

Vena8 Endothelial+ Tech Note

Endothelial cell culture Protocol

Cell-cell Adhesion Protocol

Vena8 Endothelial+ White Paper

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How does it work?

APPLICATIONS

Cell culture of endothelial cell monolayers for shear flow experiments.

Cell-cell adhesion shear flow assays on endothelial cell monolayers for studies such as:
- Cardiovascular / Atherosclerosis: primary monocyte adhesion to coronary artery endothelial cells.
- Inflammation: THP-1 monocyte adhesion to HUVECs under flow.
- Asthma / COPD: eosinophil adhesion studies to human lung microvascular endothelial cells (HMVEC-L).
- Oncology - Breast Cancer: MDA cells adhering to TNF-alpha stimulated HUVECs under shear flow.